Exchange 2013:

 

Exchange 2007/2010:

Open Exchange Management Console.

  • Click on the '+' next to Organization Configuration.
  • Select Hub Transport and select the 'Send Connectors' tab.
  • Right-click on the existing Send Connector, select 'Properties' and go to the Network tab.
  • Select "Route mail through the following smart hosts:" and click 'Add'.

Exchange 2000/2003:

Open Exchange System Manager.

  • Click on the '+' next to Connectors.
  • Right-click on the existing SMTP Connector, select 'Properties' and go to the General tab.
  • Select "forward all mail to a smart host" and write the smart host.